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Alovudine

Alovudine
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 25526-93-6
ATC code None
PubChem CID 33039
ChemSpider 30578 Yes
UNII PG53R0DWDQ Yes
KEGG D02830 Yes
ChEMBL CHEMBL105318 Yes
Chemical data
Formula C10H13F2N2O4 
Mol. mass 244.22 g/mol
SMILES
  • O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H](F)C2)CO
InChI
  • InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1 Yes
    Key:UXCAQJAQSWSNPQ-XLPZGREQSA-N Yes
 Yes (what is this?)  (verify)

Alovudine is an antiviral agent.

  • v
  • t
  • e
Antiviral drugs: antiretroviral drugs used against HIV (primarily J05)
Entry/fusion inhibitors
(Discovery & development)
  • gp41 (Enfuvirtide)
  • CCR5 (Maraviroc
  • Vicriviroc, Cenicriviroc, PRO 140)
  • CD4 (Ibalizumab)
Reverse-transcriptase
inhibitors(RTIs)
Nucleoside &
nucleotide (NRTI)
  • Nucleoside analogues/NARTIs: Abacavir (ABC)°#
  • Emtricitabine (FTC)°#
  • Lamivudine (3TC)°#
  • Didanosine (ddI)#
  • Zidovudine (AZT)#
  • Apricitabine
  • Stampidine
  • Elvucitabine
  • Racivir
  • Amdoxovir
  • Stavudine (d4T)#
  • Zalcitabine (ddC)
  • Festinavir
  • Nucleotide analogues/NtRTIs: Tenofovir°#
  • TAF
Non-nucleoside (NNRTI)
(Discovery & development)
  • (1st generation) Efavirenz°#
  • Nevirapine#
  • Loviride
  • Delavirdine
  • (2nd generation) diarylpyrimidines (Etravirine
  • Rilpivirine)
  • Lersivirine
Integrase inhibitors
  • Raltegravir°
  • Elvitegravir
  • Dolutegravir
  • Globoidnan A (experimental)
  • MK-2048
  • BI 224436
Maturation inhibitors
  • Bevirimat
  • Vivecon
Protease Inhibitors (PI)
(Discovery and development)
1stgeneration
  • Fosamprenavir°
  • Lopinavir°#
  • Nelfinavir#
  • Ritonavir#
  • Saquinavir#
  • Amprenavir
  • Indinavir#
2ndgeneration
  • Atazanavir°
  • Darunavir°
  • Tipranavir
Combined formulations
  • Lamivudine/zidovudine
  • Emtricitabine/tenofovir/efavirenz
  • Abacavir/lamivudine/zidovudine
  • Tenofovir/emtricitabine
  • Lopinavir/ritonavir
  • Abacavir/lamivudine
  • Emtricitabine/rilpivirine/tenofovir
  • Elvitegravir/cobicistat/emtricitabine/tenofovir
Experimental agents
Uncoating inhibitors
  • TRIM5alpha (gene)
Transcription inhibitors
  • Tat antagonists
Translation inhibitors
  • Trichosanthin
Other
  • Abzyme
  • Calanolide A
  • Ceragenin
  • Cyanovirin-N
  • Diarylpyrimidines
  • Epigallocatechin gallate (EGCG)
  • Foscarnet
  • Griffithsin
  • Hydroxycarbamide
  • Miltefosine
  • Portmanteau inhibitors
  • Seliciclib
  • Synergistic enhancers
  • Tre recombinase
  • Zinc finger protein transcription factor
  • KP-1461
  • Cobicistat
Failed agents
  • Dexelvucitabine
  • Capravirine
  • Emivirine
  • Lodenosine
  • Atevirdine
  • Brecanavir
  • Aplaviroc
  • #WHO-EM
  • Withdrawn from market
  • Clinical trials:
    • Phase III
    • §Never to phase III

°DHHS preferred first-line agent. Formerly or rarely used agent.

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva,infl/zost/zoon)/epon

drug(dnaa, rnaa, rtva,vacc)

  • v
  • t
  • e
DNA virus antivirals (primarily J05, also S01AD and D06BB)
Baltimore I
Herpesvirus
DNA-synthesis
inhibitor
TKactivated
Purine analogue
  • guanine (Aciclovir#/Valacyclovir
  • Ganciclovir/Valganciclovir
  • Penciclovir/Famciclovir)
  • adenine (Vidarabine)
Pyrimidine analogue
  • uridine (Idoxuridine
  • Trifluridine
  • Edoxudine)
  • thymine (Brivudine)
  • cytosine (Cytarabine)
Not TK activated
  • Foscarnet
Other
  • Docosanol
  • early protein (Fomivirsen)
  • Tromantadine
HPV/MC
  • Imiquimod/Resiquimod
  • Podophyllotoxin
Vaccinia
  • assembly: Rifampicin
Poxviridae
  • Methisazone
Hepatitis B (VII)
  • Nucleoside analogues/NARTIs: Entecavir
  • Lamivudine
  • Telbivudine
  • Clevudine
  • Nucleotide analogues/NtRTIs: Adefovir
  • Tenofovir
Multiple/general
Nucleic acid inhibitors
  • Cidofovir
Interferon
  • Interferon alfa-2b
  • Peginterferon alfa-2a
Multiple/unknown
  • Ribavirin#/Taribavirin
  • Moroxydine
  • #WHO-EM
  • Withdrawn from market
  • Clinical trials:
    • Phase III
    • §Never to phase III

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva,infl/zost/zoon)/epon

drug(dnaa, rnaa, rtva,vacc)

 

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114703-66-1 MSDS