オンライン化学データベース 搜索 | 广告

Home >> Products >> oxaflozane
 




oxaflozane

See http://ja.wikipedia.org/w/api.php for API usage

Title: Oxaflozane
CAS Registry Number: 26629-87-8
CAS Name: 4-(1-Methylethyl)-2-[3-(trifluoromethyl)phenyl]morpholine
Additional Names: 4-isopropyl-2-(a,a,a-trifluoro-m-tolyl)morpholine; tetrahydro-4-isopropyl-2-[3-(trifluoromethyl)phenyl]-2H-oxazine
Molecular Formula: C14H18F3NO
Molecular Weight: 273.29
Percent Composition: C 61.53%, H 6.64%, F 20.86%, N 5.13%, O 5.85%
Literature References: Non-tricyclic antidepressant agent. Prepn: R. Y. Mauvernay et al., FR 1564792; eidem, US 3637680 (1969, 1972 both to CERM); N. Busch et al., Eur. J. Med. Chem. – Chim. Ther. 11, 201 (1976). Improved synthesis: P. M. Weintraub et al., J. Org. Chem. 45, 4989 (1980). Pharmacological profile: J. Hache et al., Therapie 29, 81 (1974). Urinary metabolism: M. Constantin, J. F. Pognat, Arzneim.-Forsch. 29, 109 (1979). Preliminary clinical study: A. Rascol et al., Therapie 29, 95 (1974).
Properties: Oil, bp0.005 52°; bp3 99°. nD24 1.4751.
Boiling point: bp0.005 52°; bp3 99°
Index of refraction: nD24 1.4751
 
Derivative Type: Hydrochloride
CAS Registry Number: 26629-86-7
Manufacturers’ Codes: CERM-1766
Trademarks: Conflictan (Riom)
Molecular Formula: C14H18F3NO.HCl
Molecular Weight: 309.75
Percent Composition: C 54.29%, H 6.18%, F 18.40%, N 4.52%, O 5.17%, Cl 11.45%
Properties: Crystals from ethyl acetate/ethanol, mp 164°. LD50 in mice (mg/kg): 365 orally, 90 i.v. (Mauvernay, 1969); also reported as: 420 orally, 80 i.v. (Hache).
Melting point: mp 164°
Toxicity data: LD50 in mice (mg/kg): 365 orally, 90 i.v. (Mauvernay, 1969); also reported as: 420 orally, 80 i.v. (Hache)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

This entry was posted in Uncategorized by . Bookmark the permalink.
 
 
114703-66-1 MSDS